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Collagen-stimulating injections can enhance the skin in a way that looks authentic and real1—an outcome that is increasingly sought after by today’s longevity-conscious patients who want natural-looking results.2 Modern injectables are designed to be low-inflammatory,3,4 an essential characteristic of any treatment that aims to support regeneration. Here, we explore what you need to know about collagen-stimulating injections.
An established part of the aesthetic portfolio
Collagen-stimulating injections have been used for more than 20 years to enhance the skin’s natural collagen production. One of the main advantages of these treatments is their ability to deliver long-lasting results while preserving the patient’s natural appearance.5
Over the years, they have become an integral part of the aesthetic treatment portfolio, complementing other collagen-inducing procedures such as laser resurfacing, ultrasound-based therapies, and chemical peels.
Central to their success is the use of biocompatible materials that are gradually degraded by the body while stimulating new collagen formation.
Potential risk of prolonged inflammation after injection
Research suggests that injectable treatments trigger initial inflammation in the skin3 that can persist long after the procedure itself.4 While the process can stimulate collagen production, the collagen formed may be part of the skin’s healing response rather than a regenerative process that supports long-term skin health.3,4
This distinction is increasingly relevant in the context of longevity and healthy aging, as chronic, low-level inflammation has been linked to accelerated skin aging—a phenomenon often referred to as “inflamm-aging.6
How to regenerate collagen with minimal inflammation
A collagen biostimulator injection initially triggers an inflammatory response.3 The key question is not whether this response occurs, but how the skin responds over time.
The process is orchestrated by macrophages—specialised immune cells that can either sustain inflammation or promote repair and regeneration.7 The most desirable outcome is a swift transition from the initial inflammatory phase to a regenerative one.
When that transition occurs smoothly, collagen can be produced through a gradual and balanced process, while keeping inflammation to a minimum.3,4
Collagen regeneration using JULÄINE™ of Sweden
The dermal bio-activator JULÄINE™of Sweden has been developed to support the skin’s transition towards a regenerative, rather than inflammatory, response. A growing body of laboratory and clinical research suggests that it can stimulate natural collagen production while maintaining a low inflammatory profile:3,8-12
A technology that triggers low-inflammatory regeneration
In a 2025 study conducted at the Karolinska Institute in Sweden, researchers compared JULÄINE™ with a traditional PLLA biostimulator in real human skin samples from surgery during the first days following injection. JULÄINE™ was associated with increased expression of both collagen and elastin as early as the first day after treatment.3
Easy reconstitution with no aggregation
In another study conducted by K-LAB, Poland, researchers examined the design of the microparticles and how they behaved during reconstitution. Research has shown that particles that are smooth, spherical, and within an appropriate size range are less likely to trigger inflammation.8-10 The study confirmed that JULÄINE™ of Sweden possessed the desired particle characteristics and formed a homogeneous solution during reconstitution, without creating aggregates, making it easier for clinicians to administrate.11
Regeneration that smooths wrinkles and tightens the skin
In a multicenter study, researchers evaluated both the incidence of adverse events and the aesthetic results of JULÄINE™ of Sweden for the treatment of nasolabial folds. The study showed that JULÄINE™ smoothed wrinkles, tightened the skin, and enhanced overall skin quality. Adverse events were infrequent, mild in intensity, and transient, with a low incidence of moderate or severe reactions.5
What clinicians think of JULÄINE™ of Sweden
These findings are supported by real-world clinical experience. In a survey of 36 aesthetic practitioners in Spain, moderate adverse events were reported as infrequent or rare, while almost all respondents stated that they had never encountered a severe adverse event associated with the treatment.12 Together, these results contribute to the growing evidence supporting JULÄINE™’s favorable safety profile and regenerative approach to collagen stimulation.
Help your patients reveal their authentic beauty
Discover the research and clinical insights behind the studies conducted on JULÄINE™ here .
Are you an aesthetic professional? Welcome to join our inner circle by following NOTES on Instagram (@nordbergmed.notes), a closed community for open clinical dialogue.
Collagen-stimulating injections can enhance the skin in a way that looks authentic and real1—an outcome that is increasingly sought after by today’s longevity-conscious patients who want natural-looking results.2 Modern injectables are designed to be low-inflammatory,3,4 an essential characteristic of any treatment that aims to support regeneration. Here, we explore what you need to know about collagen-stimulating injections.
An established part of the aesthetic portfolio
Collagen-stimulating injections have been used for more than 20 years to enhance the skin’s natural collagen production. One of the main advantages of these treatments is their ability to deliver long-lasting results while preserving the patient’s natural appearance.5
Over the years, they have become an integral part of the aesthetic treatment portfolio, complementing other collagen-inducing procedures such as laser resurfacing, ultrasound-based therapies, and chemical peels.
Central to their success is the use of biocompatible materials that are gradually degraded by the body while stimulating new collagen formation.
Potential risk of prolonged inflammation after injection
Research suggests that injectable treatments trigger initial inflammation in the skin3 that can persist long after the procedure itself.4 While the process can stimulate collagen production, the collagen formed may be part of the skin’s healing response rather than a regenerative process that supports long-term skin health.3,4
This distinction is increasingly relevant in the context of longevity and healthy aging, as chronic, low-level inflammation has been linked to accelerated skin aging—a phenomenon often referred to as “inflamm-aging.6
How to regenerate collagen with minimal inflammation
A collagen biostimulator injection initially triggers an inflammatory response.3 The key question is not whether this response occurs, but how the skin responds over time.
The process is orchestrated by macrophages—specialised immune cells that can either sustain inflammation or promote repair and regeneration.7 The most desirable outcome is a swift transition from the initial inflammatory phase to a regenerative one.
When that transition occurs smoothly, collagen can be produced through a gradual and balanced process, while keeping inflammation to a minimum.3,4
Collagen regeneration using JULÄINE™ of Sweden
The dermal bio-activator JULÄINE™of Sweden has been developed to support the skin’s transition towards a regenerative, rather than inflammatory, response. A growing body of laboratory and clinical research suggests that it can stimulate natural collagen production while maintaining a low inflammatory profile:3,8-12
A technology that triggers low-inflammatory regeneration
In a 2025 study conducted at the Karolinska Institute in Sweden, researchers compared JULÄINE™ with a traditional PLLA biostimulator in real human skin samples from surgery during the first days following injection. JULÄINE™ was associated with increased expression of both collagen and elastin as early as the first day after treatment.3
Easy reconstitution with no aggregation
In another study conducted by K-LAB, Poland, researchers examined the design of the microparticles and how they behaved during reconstitution. Research has shown that particles that are smooth, spherical, and within an appropriate size range are less likely to trigger inflammation.8-10 The study confirmed that JULÄINE™ of Sweden possessed the desired particle characteristics and formed a homogeneous solution during reconstitution, without creating aggregates, making it easier for clinicians to administrate.11
Regeneration that smooths wrinkles and tightens the skin
In a multicenter study, researchers evaluated both the incidence of adverse events and the aesthetic results of JULÄINE™ of Sweden for the treatment of nasolabial folds. The study showed that JULÄINE™ smoothed wrinkles, tightened the skin, and enhanced overall skin quality. Adverse events were infrequent, mild in intensity, and transient, with a low incidence of moderate or severe reactions.5
What clinicians think of JULÄINE™ of Sweden
These findings are supported by real-world clinical experience. In a survey of 36 aesthetic practitioners in Spain, moderate adverse events were reported as infrequent or rare, while almost all respondents stated that they had never encountered a severe adverse event associated with the treatment.12 Together, these results contribute to the growing evidence supporting JULÄINE™’s favorable safety profile and regenerative approach to collagen stimulation.
Help your patients reveal their authentic beauty
Discover the research and clinical insights behind the studies conducted on JULÄINE™ here .
Are you an aesthetic professional? Welcome to join our inner circle by following NOTES on Instagram (@nordbergmed.notes), a closed community for open clinical dialogue.
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References
1. 2025. JULÄINE™ Instructions for Use: V4.
2. BCG medical aesthetics provider surveys; DRG Clarivate; Market participant interviews; Company 10-Ks, BCG analysis. Presented during Medical Aesthetics Injectable Summit, October 5, 2024.
3. Geara J. et al., Poly-L-Lactic Acid Microspheres Promote Skin Rejuvenation via Enhanced Fibroblast Function, Biomed Mater Res A. 2025 Nov;113(11):e38017.
4. 2024. PLLA medical device implantation study. Local Tissue Effects, Degradation and Performance Following Subcutaneous Injection in Rabbit. NAMSA Intermediate Audited Report. Data on file.
5. Urdiales-Gálvez F, Benítez PA, Díaz I, Clinical Outcomes of an Innovative Poly-L-Lactic Acid (LASYNPRO) in Facial Rejuvenation: Prospective, Multicenter Spanish Study, J Cosmet Dermatol. 2026 Feb;25(2):e70753.
6. Pilkington S.M. et al, Inflammaging and the Skin, Invest Dermatol. 2021 Apr;141(4S):1087-1095
7. Oh S. et al. Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin. Cells 2023, 12, 1320.
8. Matlaga B.F., Yasenchak L.P., Salthouse N.T., Tissue response to implanted polymers: the significance of sample shape, J Biomed Mater Res. 1976 May;10(3):391-7.
9. Vaine CA et al., Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation, J Immunol. 2013 Apr 1;190(7):3525-32.
10. Guo J. et al., Injectable fillers: current status, physicochemical properties, function mechanism, and perspectives, RSC Adv. , 2023, 13, 23841-23858.
11. Comparative Analysis of Reconstitution and Solubility of Two Poly-L-Lactic Acid Fillers for Medical Applications Pawel Kubik , Wojciech Gruszczyński and Monika Filipowska, Polymers (Basel). 2025 Jun 27;17(13):1778.
12. Serrano-Coronado M. et al., Clinical Perspectives on the Safety Profile of Poly-L-Lactic Acid (Juläine): Results From a National Survey, J Cosmet Dermatol. 2025 Sep 8;24(9):e70439.
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