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Are there biostimulators with low inflammation?
Over the last years, there has been growing concern that collagen biostimulators may lead to prolonged inflammation in the skin. Modern biostimulators have been developed to promote collagen regeneration in a low-inflammatory way. It all comes down to the microparticle design.
What are the negative effects of inflammation in the skin?
Any aesthetic treatment—whether biostimulators, fillers, or neurotoxins—may trigger a short-term inflammatory response. However, there is also a risk that the inflammatory response becomes prolonged.1
Chronic, low-grade inflammation has been associated with accelerated aging; a phenomenon known as inflammaging.2
For this reason, it is worth considering whether aesthetic treatments might contribute to chronic skin inflammation and selecting options that minimize long-term inflammatory responses.
What are biostimulators?
Biostimulators are injectable treatments designed to stimulate the skin to increase its production of collagen. Collagen is produced by specialized cells called fibroblasts that reside in the dermis, the middle layer of the skin.
By activating the fibroblasts to produce new collagen, biostimulators help restore the skin’s firmness and thickness, and improve overall skin quality.3
Utilizing modern biostimulator design, collagen regeneration can be achieved while minimizing unnecessary inflammation.3-5
Product design that minimizes inflammation
The microscopic structure of a biomaterial can significantly influence how the skin responds to treatment. Key factors include:
● Microparticle shape: Spherical, smooth particles integrate best with the tissue and help minimize inflammation.6
● Surface texture: Smooth surfaces have a lower risk of triggering immune activation compared with rough or irregular textures.7
● Particle size: Particles that range between 20–50 microns are ideal, as both smaller and larger particles may provoke stronger inflammatory responses.8
What is the evidence that microparticle design matters?
LASYNPRO™ is a new biostimulator technology designed to minimize inflammation. It is made from poly-L-lactic acid (PLLA), a biodegradable polymer made of natural lactic acid.
A recent study at the Karolinska Institute, Sweden, showed that LASYNPRO™:5
● Activates fibroblasts: Stimulates the production of collagen, elastin, and other key skin components
● Regenerates: Supports the natural regeneration of new collagen
● Minimizes inflammation: Triggers minimal immune response compared to conventional PLLA biostimulators
In short, identical materials can behave very differently in the skin depending on microscale particle design. This includes not only the design itself, but also the capability of the microparticle to maintain its spherical shape while being degraded by the body over the course of a year or longer.1,5
Low-inflammatory collagen regeneration in clinical practice
What truly matters, however, are the results seen in patients. Clinical studies confirm what lab tests have shown about LASYNPRO™:
● A study in Journal of Cosmetic Dermatology reported that it smoothens wrinkles and tightens the skin, with adverse events being infrequent, mild in intensity, and transient, with a low incidence of moderate or severe events.3
● In a national survey in Spain comprising 36 aesthetic practitioners, serious adverse events (infections, nodules, ulcerations, or ischemia) were reported as never observed or rare.9
These findings underscore that LASYNPRO™ promotes low-inflammatory collagen regeneration, while providing patients effective long-term skin rejuvenation.3
The LASYNPRO™ technology is exclusive to the dermal bio-activator JULÄINE™.
Interested in starting with JULÄINE? Connect with us!
Are you an aesthetic practitioner interested in introducing JULÄINE™ at your clinic?
Connect with our team to become part of our community and to get access to an extensive range of scientific and hands-on training and education in the field of regenerative aesthetics.
Learn more about JULÄINE™ and what aesthetic practitioners are saying about the treatment.
Are there biostimulators with low inflammation?
Over the last years, there has been growing concern that collagen biostimulators may lead to prolonged inflammation in the skin. Modern biostimulators have been developed to promote collagen regeneration in a low-inflammatory way. It all comes down to the microparticle design.
What are the negative effects of inflammation in the skin?
Any aesthetic treatment—whether biostimulators, fillers, or neurotoxins—may trigger a short-term inflammatory response. However, there is also a risk that the inflammatory response becomes prolonged.1
Chronic, low-grade inflammation has been associated with accelerated aging; a phenomenon known as inflammaging.2
For this reason, it is worth considering whether aesthetic treatments might contribute to chronic skin inflammation and selecting options that minimize long-term inflammatory responses.
What are biostimulators?
Biostimulators are injectable treatments designed to stimulate the skin to increase its production of collagen. Collagen is produced by specialized cells called fibroblasts that reside in the dermis, the middle layer of the skin.
By activating the fibroblasts to produce new collagen, biostimulators help restore the skin’s firmness and thickness, and improve overall skin quality.3
Utilizing modern biostimulator design, collagen regeneration can be achieved while minimizing unnecessary inflammation.3-5
Product design that minimizes inflammation
The microscopic structure of a biomaterial can significantly influence how the skin responds to treatment. Key factors include:
● Microparticle shape: Spherical, smooth particles integrate best with the tissue and help minimize inflammation.6
● Surface texture: Smooth surfaces have a lower risk of triggering immune activation compared with rough or irregular textures.7
● Particle size: Particles that range between 20–50 microns are ideal, as both smaller and larger particles may provoke stronger inflammatory responses.8
What is the evidence that microparticle design matters?
LASYNPRO™ is a new biostimulator technology designed to minimize inflammation. It is made from poly-L-lactic acid (PLLA), a biodegradable polymer made of natural lactic acid.
A recent study at the Karolinska Institute, Sweden, showed that LASYNPRO™:5
● Activates fibroblasts: Stimulates the production of collagen, elastin, and other key skin components
● Regenerates: Supports the natural regeneration of new collagen
● Minimizes inflammation: Triggers minimal immune response compared to conventional PLLA biostimulators
In short, identical materials can behave very differently in the skin depending on microscale particle design. This includes not only the design itself, but also the capability of the microparticle to maintain its spherical shape while being degraded by the body over the course of a year or longer.1,5
Low-inflammatory collagen regeneration in clinical practice
What truly matters, however, are the results seen in patients. Clinical studies confirm what lab tests have shown about LASYNPRO™:
● A study in Journal of Cosmetic Dermatology reported that it smoothens wrinkles and tightens the skin, with adverse events being infrequent, mild in intensity, and transient, with a low incidence of moderate or severe events.3
● In a national survey in Spain comprising 36 aesthetic practitioners, serious adverse events (infections, nodules, ulcerations, or ischemia) were reported as never observed or rare.9
These findings underscore that LASYNPRO™ promotes low-inflammatory collagen regeneration, while providing patients effective long-term skin rejuvenation.3
The LASYNPRO™ technology is exclusive to the dermal bio-activator JULÄINE™.
Interested in starting with JULÄINE? Connect with us!
Are you an aesthetic practitioner interested in introducing JULÄINE™ at your clinic?
Connect with our team to become part of our community and to get access to an extensive range of scientific and hands-on training and education in the field of regenerative aesthetics.
Learn more about JULÄINE™ and what aesthetic practitioners are saying about the treatment.
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References:
1. 2024. PLLA medical device implantation study. Local Tissue Effects, Degradation and Performance Following Subcutaneous Injection in Rabbit. NAMSA Intermediate Audited Report. Data on file.
2. Pilkington S.M. et al, Inflammaging and the Skin, Invest Dermatol. 2021 Apr;141(4S):1087-1095
3. Urdiales-Gálvez F. et al., Facial Rejuvenation With an Innovative Poly-l-Lactic Acid (Juläine) for Nasolabial Folds: Interim Data Analysis of a Prospective, Non-Randomized, Multicenter, Open-Label Spanish Study, Cosmet Dermatol. 2025 Apr;24(4):e70137.
4. Oh S. et al. Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin. Cells 2023, 12, 1320.
5. Geara J. et al., Poly-L-Lactic Acid Microspheres Promote Skin Rejuvenation via Enhanced Fibroblast Function, Biomed Mater Res A. 2025 Nov;113(11):e38017.
6. Matlaga B.F., Yasenchak L.P., Salthouse N.T., Tissue response to implanted polymers: the significance of sample shape, J Biomed Mater Res. 1976 May;10(3):391-7.
7. Vaine CA et al., Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation, J Immunol. 2013 Apr 1;190(7):3525-32.
8. Guo J. et al., Injectable fillers: current status, physicochemical properties, function mechanism, and perspectives, RSC Adv. , 2023, 13, 23841-23858.
9. Serrano-Coronado M. et al, Clinical Perspectives on the Safety Profile of Poly-L-
Lactic Acid (Juläine): Results From a National Survey, J Cosmet Dermatol. 2025 Sep 8;24(9):e70439.
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