Particle design shapes tissue response.
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The evidence base for JULÄINE™ of Sweden
The science of collagen regeneration: A study on PLLA particles.
For Nordberg Medical, regeneration is not just a promise – it is a measurable biological process rooted in science. It begins deep within the skin, when fibroblasts reactivate and rebuild collagen from within.
Four scientific publications bring conclusions that show how particle morphology shapes the biological tissue response. A scientific approach built on evidence.
The evidence base for JULÄINE™ of Sweden, formulated with PLLA-LASYNPRO™ microsphere technology, is supported by four peer-reviewed publications, each contributing different insights into its efficacy, safety, and mechanism of action. Geara et al. explored the mechanism of action in ex-vivo human skin models. Separate clinical and real-world studies demonstrated sustained wrinkle improvement alongside a favourable safety profile. Together, these findings highlight that particle design plays a critical role in determining both therapeutic efficacy and safety.
JULÄINE™ of Sweden microspheres penetrate deep into the reticular dermis and disperse distribute evenly, without injection-site aggregation
Microspheres activate pro-regenerative pathways and stimulate ECM renewal across collagen, elastin and fibronectin
Progressive, sustained wrinkle improvement over 6 months with biological evidence of collagen stimulation
Over 90% of practitioners never or partly reported severe adverse events such as nodules and granulomas as rare or never observed
Particle design shapes the biological tissue response - presented across mechanism of action, clinical effectiveness and real-world safety
*ECM = extracellular matrix
What the evidence means in daily clinical practice.
Three implications of the Karolinska Institute findings for the way you work with JULÄINE™ of Sweden.
Even tissue coverage. Lower risk of localised aggregation.
JULÄINE™ of Sweden distributes uniformly through the dermis. The smooth, spherical microspheres do not aggregate at the injection site, supporting consistent tissue coverage across the treated area.
Regeneration with reduced inflammation.
The low-inflammatory profile of JULÄINE™ of Sweden minimises cellular friction and tissue irritation, favouring biointegration over inflammation-driven stimulation. JULÄINE™ of Sweden activates the regenerative cascade without triggering the inflammatory signalling that compromises tissue quality.
Comprehensive ECM renewal
JULÄINE™ of Sweden supports the stimulation of collagen, elastin and fibronectin production across the full extracellular matrix. The result is structural tissue regeneration, not isolated volumisation.
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Take the evidence with you.
Sign up to receive the JULÄINE™ digital scientific brochure, including clinical outcomes, safety data, and insights into our unique PLLA microsphere technology - designed to support patient consultations and professional education.
The Karolinska Institute findings, translated for clinical practice.
What does the Geara et al. data mean at the chair side? Our new article translates the in vitro and ex vivo findings into clinical relevance – written for healthcare professionals who want to understand the evidence behind JULÄINE™ of Sweden. Read more about particle morphology, fibroblast activation, ECM renewal and the safety implications of a low-inflammatory regenerative profile.
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Join the inner circle.
@nordbergmed.notes is an aesthetic professionals only Instagram account. Access exclusive clinical resources, partner clinic spotlights, and meaningful conversations with industry experts inside the community where clinical thinking lives.
What you find there:
@nordbergmed.notes is an aesthetic professionals only Instagram account. Access exclusive clinical resources, partner clinic spotlights, and meaningful conversations with industry experts inside the community where clinical thinking lives.
What you find there:
Study spotlights from the four JULÄINE™ of Sweden publications.
Particle morphology and mechanism of action briefs.
Clinical peer to peer discussions.
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Follow @nordbergmed.notes
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Your patients find everything they need on the JULÄINE™ of Sweden website – clearly structured, easy to follow, and in a voice they will recognise.
Beauty isn't created. It's revealed.
Go to JULÄINE™ of Sweden
Designed at particle level. Proven across four peer-reviewed publications.
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Kubik et al., Polymers, 2025. Stable, homogeneous reconstitution with smooth spherical microspheres (15–50 μm) at all timepoints.
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Urdiales-Gálvez et al., J Cosmet Dermatol, 2025. Progressive, sustained wrinkle improvement over 6 months in nasolabial folds. Biomarker-confirmed neocollagenesis.
Read the full article
Geara et al., Karolinska Institute, J Biomed Mater Res A, 2025. JULÄINE™ of Sweden microspheres activated pro-regenerative signalling and stimulated full extracellular matrix renewal across collagen, elastin and fibronectin. Particle morphology shapes the biological tissue response.
Read the full article
Serrano-Coronado et al., J Cosmet Dermatol, 2025. Over 90% of practitioners report severe adverse events such as nodules and granulomas as rare or never observed.
Read the full article