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Where research becomes impact
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Reconstitution and solubility of PLLA-LASYNPRO™ using in vitro analysis
PLLA-LASYNPRO™ exhibited rapid, uniform reconstitution, producing a homogeneous milky-white solution with no foam formation. Microscopic analysis revealed consistent particle morphology; the small, uniform, spherical particles may contribute to a reduced inflammatory response in aesthetic applications.
Source: Comparative Analysis of Reconstitution and Solubility of Two Poly-L-Lactic Acid Fillers for Medical Applications Pawel Kubik , Wojciech Gruszczyński and Monika Filipowska, Polymers (Basel). 2025 Jun 27;17(13):1778. https://www.mdpi.com/2073-4360/17/13/1778
The unique potential of JULÄINE™
A recent publication highlights the unique potential of JULÄINE™, a PLLA-based injectable (PLLA-LASYNPRO™), developed to activate collagen and extracellular matrix regeneration without provoking significant inflammation. Initial clinical findings demonstrate improvements in facial volume and skin texture, particularly in the nasolabial region, reinforcing JULÄINE™’s role in regenerative aesthetics.
Source (in smaller font) Facial Rejuvenation With an Innovative Poly-l-Lactic Acid (Juläine) for Nasolabial Folds: Interim Data Analysis of a Prospective, Non-Randomized, Multicenter, Open-Label Spanish Study, Urdiales-Gálvez F., Benítez P.A., Díaz https://pubmed.ncbi.nlm.nih.gov/40135677/
The safety profile of JULÄINE™
A survey with 36 practitioners across Spain assessed JULÄINE™’s safety. Most respondents (47.2%) had 3–6 months’ experience with the product. Despite concerns regarding potential nodule formation with PLLA fillers, the incidence was extremely rare or absent, with mild adverse events being transient. Findings align with existing literature, showing that most patients did not experience significant adverse events.
