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JULÄINE™: Clarity in design. Continuity in science.

Not all PLLA materials are the same. JULÄINE™ of Sweden unveils a refined look with the same LASYNPRO™ microsphere technology.

BlogsMarch 23, 20265 min reading
New look for JULÄINE™ of Sweden

Our dermal bio-activator JULÄINE™ of Sweden offers unique benefits for both patients and practitioners. To better communicate these benefits, we are revealing an updated look and clear messaging for JULÄINE™.

A shift toward wellness-driven aesthetics

There is a profound shift in aesthetic medicine. Today’s patients are moving beyond instant transformations and overtreated appearances. Instead, they seek subtle, long-term improvements—healthier skin, a natural lift, and a gradual softening of wrinkles.1

This shift aligns closely with the growing interest in longevity and lifelong wellness, with patients opting for interventions that support the body’s own regenerative potential.1

Regeneration instead of biostimulation

The growing interest in health and longevity has led to the emergence of regenerative aesthetics. While the term is still evolving, a useful distinction can be made between biostimulation and true regeneration.

All aesthetic treatments work by activating an immediate immune response2 that sometimes leads to prolonged inflammation. Persistent inflammation may contribute to accelerated aging, known as inflammaging.3 Newer approaches for collagen regeneration instead aim to keep inflammation to a minimum.4

JULÄINE™ offers something different

Aesthetic treatments often center on restoring collagen—the structural foundation that provides skin firmness and resilience. Although regeneration is a common marketing promise, few products truly deliver the low-inflammatory, gradual, and lasting effects that patients and practitioners desire. 

In today’s evolving aesthetic landscape, JULÄINE™ represents a new standard.

A technology to support bio-regeneration

All so-called regenerative injectables are not the same. At the core of JULÄINE™ lies a unique technology, LASYNPRO™, which uses intelligently designed lactic acid (PLLA) microspheres that progressively stimulate collagen production while minimizing immune activation.5-7 The technology was developed with a clear purpose—to advance the field of bio-regeneration and enable authentic aesthetic results.

The unique design of the microparticles is what makes the difference. LASYNPRO™ / JULÄINE™ has been studied through multiple scientific methods, including analyses of microspheres during reconstitution,8 histological imaging over a one-year period,5,6 and clinical studies, demonstrating effective skin tightening and improved skin quality with a strong safety profile.9,10

JULÄINE™ is different, and both practitioners and patients deserve to understand what makes it so. 

Beauty isn’t created, it’s revealed

To communicate this difference—and to ensure this bio-regenerative solution receives the recognition it deserves—JULÄINE™ now features a new look, including an updated packaging and clearer messaging.

 The essence is that our biostimulator JULÄINE™ smoothens wrinkles and tightens the skin by activating fibroblasts to regenerate healthy collagen in a low-inflammatory way. It progressively delivers long-lasting, natural-looking results that feel authentic and real. Because the most powerful kind of beauty isn‘t created. It‘s revealed.

What stays

While the design of the packaging has been modified, the formulation remains unchanged. It is the same PLLA-LASYNPRO™ microsphere technology, the same strong safety profile, and the same long-lasting, natural-looking results.

The strong market response confirms that JULÄINE™ offers something unique. Demand is growing, and we support this expansion through science-based education and training, and a growing community for knowledge exchange.

Throughout this process, our commitment remains unchanged: to develop advanced biomaterials that unlock the body’s regenerative potential in medical aesthetics and beyond.

Product enquires

For product enquiries or questions on our science, please connect with us here.

New look for JULÄINE™ of Sweden
New look for JULÄINE™ of Sweden

References:

1. BCG medical aesthetics provider surveys; DRG Clarivate; Market participant interviews; Company 10-Ks, BCG analysis. Presented during Medical Aesthetics Injectable Summit, October 5, 2024.

2. Ganceviciene R. et al, Skin anti-aging strategies, Dermatoendocrinol. 2012;4(3):308–319.

3. Pilkington S.M. et al, Inflammaging and the Skin, Invest Dermatol. 2021 Apr;141(4S):1087-1095

4. Goldie K, The evolving field of regenerative aesthetics, J Cosmet Dermatol. 2023 Mar:22 Suppl 1:1-7.

5. 2024. PLLA medical device implantation study. Local Tissue Effects, Degradation and Performance Following Subcutaneous Injection in Rabbit. NAMSA Intermediate Audited Report. Data on file.

6. Geara J. et al., Poly-L-Lactic Acid Microspheres Promote Skin Rejuvenation via Enhanced Fibroblast Function, J Biomed Mater Res A. 2025 Nov;113(11):e38017.

7. 2024. Juläine Instructions for Use: V10 - 03.06.2024.

8. Comparative Analysis of Reconstitution and Solubility of Two Poly-L-Lactic Acid Fillers for Medical Applications Pawel Kubik , Wojciech Gruszczyński and Monika Filipowska, Polymers (Basel). 2025 Jun 27;17(13):1778.

9. Urdiales-Gálvez et al: Facial Rejuvenation With an Innovative Poly-l-Lactic Acid (Juläine) for Nasolabial Folds: Interim Data Analysis of a Prospective, Non-Randomized, Multicenter, Open-Label Spanish Study. Journal of Cosmetic Dermatology, 2025; 24:e70137

10. Serrano-Coronado M. et al, Clinical Perspectives on the Safety Profile of Poly-L-

Lactic Acid (Juläine): Results From a National Survey, J Cosmet Dermatol. 2025 Sep 8;24(9):e70439.

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