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Many of today’s aesthetic consumers are embracing a growing awareness of the importance of feeling good from within. Rather than striving to look as young as possible, they are drawn to innovative aesthetic treatments that enhance natural features and promote a healthy, refreshed appearance.1
Biohacking—the art of fine-tuning your own biology—has even become a buzzword. With regenerative biomaterials, clinics can meet these demands and attract new, high-value target groups.
The evolving consumer demands have led to a new branch of aesthetic medicine—regenerative aesthetics. Whereas regenerative medicine seeks to replace tissue that has been lost or damaged due to disease or trauma, the goal of regenerative aesthetic treatments is to regenerate soft tissue that has been lost or damaged due to the aging process.2
Regenerative aesthetics has the potential to attract a new set of patients, people interested in biohacking and longevity. They belong to a segment of consumers who would perhaps not consider a dermal filler procedure but desire to achieve lasting skin health via innovative and biocompatible technologies.
Thanks to recent scientific advances, biomaterials have evolved from providing inert support (such as titanium or ceramic materials) to bioactive materials that are able to trigger or promote the regenerative potential of tissues.3 This makes them very interesting to use in skin care applications.
Regenerative treatments, whether they are cell based (stem cells), based on bio cues (growth factors), or based on biomaterials, are required to meet certain standards: They must be able to promote tissue regeneration in the body and skin without causing damage to the donor site, risk prosthetic rejection, or lead to long-term infection.4
Regenerative treatments must also be meaningful for the aesthetic patient and lead to visible and natural-looking skin rejuvenation, with minimal or no downtime, and little to no long-term side-effects.
Poly-L-lactic acid, PLLA, is a polymer consisting of repeating units of L-lactic acid, a naturally occurring molecule in the body and skin. L-lactic acid plays a protective role in maintaining skin health. In recent years, research has demonstrated that L-lactic acid works as a physical physical signaling molecule that protects skin cells from dysfunction and premature aging.5
PLLA is biodegradable, breaking down into harmless L-lactic acid, making it suitable for aesthetic products.6
The design of the PLLA material is essential, and this is where innovation comes into the picture. Research has established that round and smooth microspheres of PLLA provide the best results in terms of tissue integration and in minimizing inflammatory response.7-10 Learn more here why particle properties are key in biostimulator injections.
JULÄINE™ has been designed for aesthetic professionals seeking to offer their patients a proven collagen regenerative treatment—the very sort of treatment that many patients are looking for today.
Using our proprietary PLLA-based LASYNPRO™ microsphere technology, JULÄINE™ sets a new standard in bio-regenerative injectables design.11 It progressively11 delivers long-lasting,9 natural looking results through collagen regeneration in a low-inflammatory way.9,12
Due to its unique microsphere design,11,13 JULÄINE™ shows low aggregation,14 allows easy injection, integrates smoothly into the tissue9 and has a strong safety profile15. Find out more about the reconstitution and solubility of JULÄINE™ here .
As a healthcare professional using JULÄINE™, you become part of a collaborative and supportive community where we grow together. We are committed to empowering you with the knowledge and resources you need to deliver exceptional results. Contact us here for more details and to begin your journey with us.
Many of today’s aesthetic consumers are embracing a growing awareness of the importance of feeling good from within. Rather than striving to look as young as possible, they are drawn to innovative aesthetic treatments that enhance natural features and promote a healthy, refreshed appearance.1
Biohacking—the art of fine-tuning your own biology—has even become a buzzword. With regenerative biomaterials, clinics can meet these demands and attract new, high-value target groups.
The evolving consumer demands have led to a new branch of aesthetic medicine—regenerative aesthetics. Whereas regenerative medicine seeks to replace tissue that has been lost or damaged due to disease or trauma, the goal of regenerative aesthetic treatments is to regenerate soft tissue that has been lost or damaged due to the aging process.2
Regenerative aesthetics has the potential to attract a new set of patients, people interested in biohacking and longevity. They belong to a segment of consumers who would perhaps not consider a dermal filler procedure but desire to achieve lasting skin health via innovative and biocompatible technologies.
Thanks to recent scientific advances, biomaterials have evolved from providing inert support (such as titanium or ceramic materials) to bioactive materials that are able to trigger or promote the regenerative potential of tissues.3 This makes them very interesting to use in skin care applications.
Regenerative treatments, whether they are cell based (stem cells), based on bio cues (growth factors), or based on biomaterials, are required to meet certain standards: They must be able to promote tissue regeneration in the body and skin without causing damage to the donor site, risk prosthetic rejection, or lead to long-term infection.4
Regenerative treatments must also be meaningful for the aesthetic patient and lead to visible and natural-looking skin rejuvenation, with minimal or no downtime, and little to no long-term side-effects.
Poly-L-lactic acid, PLLA, is a polymer consisting of repeating units of L-lactic acid, a naturally occurring molecule in the body and skin. L-lactic acid plays a protective role in maintaining skin health. In recent years, research has demonstrated that L-lactic acid works as a physical physical signaling molecule that protects skin cells from dysfunction and premature aging.5
PLLA is biodegradable, breaking down into harmless L-lactic acid, making it suitable for aesthetic products.6
The design of the PLLA material is essential, and this is where innovation comes into the picture. Research has established that round and smooth microspheres of PLLA provide the best results in terms of tissue integration and in minimizing inflammatory response.7-10 Learn more here why particle properties are key in biostimulator injections.
JULÄINE™ has been designed for aesthetic professionals seeking to offer their patients a proven collagen regenerative treatment—the very sort of treatment that many patients are looking for today.
Using our proprietary PLLA-based LASYNPRO™ microsphere technology, JULÄINE™ sets a new standard in bio-regenerative injectables design.11 It progressively11 delivers long-lasting,9 natural looking results through collagen regeneration in a low-inflammatory way.9,12
Due to its unique microsphere design,11,13 JULÄINE™ shows low aggregation,14 allows easy injection, integrates smoothly into the tissue9 and has a strong safety profile15. Find out more about the reconstitution and solubility of JULÄINE™ here .
As a healthcare professional using JULÄINE™, you become part of a collaborative and supportive community where we grow together. We are committed to empowering you with the knowledge and resources you need to deliver exceptional results. Contact us here for more details and to begin your journey with us.
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1. BCG medical aesthetics provider surveys; DRG Clarivate; Market participant interviews; Company 10-Ks, BCG analysis. Presented during Medical Aesthetics Injectable Summit, October 5, 2024.
2. Goldie K, The evolving field of regenerative aesthetics, J Cosmet Dermatol. 2023 Mar:22 Suppl 1:1-7.
3. Cao D. Ding J., Recent advances in regenerative biomaterials, Regen Biomater. 2022 Dec 5:9:rbac098.
4. Li H. et al, Recent progress and clinical applications of advanced biomaterials in cosmetic surgery, Regen Biomater. 2023 Feb 7:10:rbad005.
5. Chirumbolo, Bertossi, Magistretti. 2023, Insights into the Role of L-Lactate as a Signaling Molecule in Skin Aging. Biogerontology (2023) 24:709-726.
6. Capuana E. Et al., Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications, Polers (Basel). 2022 Mar 14;14(6):1153.
7. B F Matlaga, L P Yasenchak, T N Salthouse, Tissue response to implanted polymers: the significance of sample shape, J Biomed Mater Res. 1976 May;10(3):391-7.
8. Vaine CA et al., Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation, J Immunol. 2013 Apr 1;190(7):3525-32.
9. 2024. PLLA medical device implantation study. Local Tissue Effects, Degradation and Performance Following Subcutaneous Injection in Rabbit. NAMSA Intermediate Audited Report. Data on file.
10. Geara J. et al., Poly-L-Lactic Acid Microspheres Promote Skin Rejuvenation via Enhanced Fibroblast Function, omed Mater Res A. 2025 Nov;113(11):e38017.
11. 2024. JULÄINE™ Instructions For Use.
12. 2025. Study on comparative effects of LaSynPro™ (PLLA microsphere) and PLLA-SCA on skin regeneration and inflammation. Data on file.
13. 2023. Study performed by Research Institute of Sweden AB (RISE). Data on file.
14. Comparative Analysis of Reconstitution and Solubility of Two Poly-L-Lactic Acid Fillers for Medical Applications Pawel Kubik , Wojciech Gruszczyński and Monika Filipowska, Polymers (Basel). 2025 Jun 27;17(13):1778.
15. Urdiales et Al. 2025, Facial Rejuvenation With an Innovative Poly-l-Lactic Acid (Juläine) for Nasolabial Folds: Interim Data Analysis of a Prospective, Non-Randomized, Multicenter, Open-Label Spanish Study, Journal of Cosmetic Dermatology, 2025; 24:e70137